European training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality

In this study, we assess the potential applicability of three anti-biofilm compounds as part of implanted medical devices by testing them on in vitro systems that more faithfully resemble the clinical scenario. To that end, we used a competition model based on the co-culture of SaOS-2 mammalian cells and Staphylococcus aureus (collection and clinical strains) on a titanium surface, as well as titanium pre-conditioned with serum proteins. This study emphasizes and demonstrates the importance of using meaningful experimental models, where potential antimicrobials ought to be tested for protection of biomaterials in translational applications.

Read the original article, published in Microorganisms 2020, here.